Cell fate decisions in mammalian embryogenesis

ER71 directs mesodermal fate decisions during embryogenesis.

Er71 mutant embryos are nonviable and lack hematopoietic and endothelial lineages. To further define the functional role for ER71 in cell lineage decisions, we generated genetically modified mouse models. We engineered an Er71-EYFP transgenic mouse model by fusing the 3.9 kb Er71 promoter to the EYFP reporter gene. Using FACS and transcriptional profiling, we examined the EYFP(+) population of ...

Early events leading to fate decisions during leech embryogenesis.

This paper reviews leech development up to the 12-cell embryo. Oogenesis proceeds by a system of nurse cells that contribute to oocyte growth via continuous cytoplasmic connections. Development begins when fertilized eggs are deposited: formation of the polar bodies, and centration of the male and female pro-nuclei is accompanied by cytoskeletal contractions, and formation of teloplasm (yolk-fr...

Cell mingling during mammalian embryogenesis.

Oxygen and Cell Fate Decisions

Molecular oxygen has been known to play a critical role in a wide range of biological processes including glycolysis, mitochondrial respiration, angiogenesis, pulmonary functions, and cardiovascular activities. An emerging theme has developed in recent years that oxygen has significant impact on embryonic development, maintenance of stem cells, and cellular differentiation or cell fate decision...

Progenitor Cell Fate Decisions in Mammary Tumorigenesis

Crowe DL, Wan R, Baloue K. 2011. Coordinate activation of the NBS1 gene regulates estradiol mediated protection from double strand DNA breaks. Era of Hope Breast Cancer Research Meeting. Orlando, FL Published manuscripts: Wan R, Crowe DL. 2012. Haploinsufficiency of the Nijmegen breakage syndrome 1 gene increases mammary tumor latency and metastasis. Int J Oncol 41:345-352 Wan R, Wu J, Baloue K...